Studies have noted that individuals with a history of heavy alcohol consumption tend to exhibit a higher prevalence of Dupuytren’s contracture. Chronic alcohol use can lead to liver damage, which in turn can cause alterations in collagen metabolism—an essential component of connective tissue., Abstract Reported alcohol consumption was quantified and scored by a validated questionnaire administered by an interviewer to 64 patients (10 female) with Dupuytren's contracture (DC) before hand surgery and to 89 controls (44 female) admitted for other hand or foot surgery., Our Mendelian Randomization study establishes a causal association between alcohol consumption and DD, unlike smoking, underscoring alcohol’s role in DD etiology., Alcohol consumption among the population at large with DC may also be much higher because some may not have reached surgery through unfit-ness associated with alcohol abuse., Alcohol intake, particularly heavy and prolonged use, is associated with an increased risk of Dupuytren’s Contracture. While alcohol alone may not be the sole cause of Dupuytren’s Contracture, it is advisable for those at risk to moderate their alcohol intake., • This prospective study was undertaken to assess the prevalence of Dupuytren's contracture (DC) and its relationship with possible causes, especially alcohol consumption and chronic liver disease..