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схема вязания спицами шапок для детей от 0 до 3 лет, The Current Status of Gene Therapy for the Treatment of Cancer, What is Gene Therapy? - OncoLink, How is Gene Therapy Being Used to Treat Cancer? - Dana-Farber Cancer , How CRISPR Is Changing Cancer Research and Treatment, Cancer Gene Therapy - Nature, Cancer gene therapy: Understanding the basics - Alliance for Cancer , Gene Therapy Treatment - Dana-Farber Cancer Institute.
After DNA helical structure discovery, the world continuous staircase outburst of several advanced technologies, which are currently heading toward translation into clinical practice. Over the last decades, several molecular techniques developed that help to edit the DNA codes and modify mRNA by post-transcriptional modifications. Gene therapy is the delivery of specific genetic material to modify the encoding of a gene product or to change the biological properties of tissues for the management of various disorders. Gene therapy overcomes the limitations associated with the recombinant therapeutic use of peptides, such as low bioavailability, instability, severe toxicity, clearance rates, and high production cost. Gene therapies act by different mechanisms including, replacing malfunction genes with the therapeutic genes, gene knockdown, or deactivating problem genes, and insert a new gene to treat a disease. Gene therapy can be done in either somatic or germline cells. In somatic cells, gene therapy only the modified tissues will be affected, but in germline cell gene therapy, genetic changes transmit to the offspring. So, there is no clinical trial on human germline gene therapy. Currently, somatic gene therapy is safe for the management of several disorders in human beings. Gene therapy effectively treats several diseases due to increased understanding of disease pathogenesis and improved gene delivery technologies. Gene therapy uses genetic material (ie, RNA or DNA) via a vector that facilitates the delivery of foreign genetic material into the host organ. The genetic material is administered into the target organ (in vivo gene therapy) or used to modify cells taken from the host that are then re-administered (ex vivo gene therapy). Gene therapy aims to provide a functional gene copy of the damaged gene(s), increase the availability of disease-modifying genes or suppress the activity of a damaged gene., Gene therapy has a broad spectrum of applications, from gene replacement and knockdown for genetic disorders including cancer, hemophilia, hypercholesterolemia, and neurodegenerative diseases to vaccination, each with different requirements for gene administration. Gene delivery systems consist of three components: a gene that expresses essential therapeutic peptides, a plasmid-based gene encoding system that regulates the activity of a gene in the target organ, and a gene delivery system that regulates the administration of the encoding gene to host tissue.Gene Editing Tools, Gene therapy for cancer treatment has good progress in the last three decades, few drugs approved, while others are still in trials. Relatively gene therapy has better safety with tolerable adverse effects than chemotherapy for the treatment of cancer. In the future, tumor genomic analysis, assessment of host humoral and cellular immunity will , Stop certain genes that can cause new cancer or the spread of an existing cancer (called “metastasis”). These genes are called “Oncogenes.” By stopping these genes, the cancer and/or its spread may be stopped. Use the body's own immune system by putting genes into cancer cells that trigger the body to attack the cancer cells as foreign .
The first therapeutic cancer vaccine to receive FDA approval is used in the treatment of certain prostate cancer patients. The goal is that the newly inserted gene will cause the cancer cells to die or interrupt some process required for survival, such as preventing cancer cells and surrounding tissue from funneling blood to tumors and , CRISPR is a fairly new and highly precise gene editing tool that is changing cancer research and treatment. Researchers are using CRISPR to study how cancer grows and to find new potential treatments. CRISPR-based therapies are also being tested in trials of people with cancer., Cancer Gene Therapy is the essential gene therapy resource for cancer researchers and clinicians, keeping readers up to date with the latest developments in gene therapy for cancer., Gene therapy is an element of cancer cell and gene therapy in which researchers alter the DNA and genetic function of immune cells or cancer cells. Researchers are also examining the tumor microenvironment – the environment cancer builds around it to support its growth and block the immune system – of different types of cancers to learn how , Gene therapy aims to correct the gene to treat the disease by: Adding a new or modified copy of a gene; Turning a gene on or off; Changing a gene, by replacing the part of the gene causing disease with a healthy copy; Types of Gene Therapy. The two main types of gene therapy are gene addition and gene editing., Gene therapy aims to fix a faulty gene or replace it with a healthy gene to try to cure disease or make the body better able to fight disease. It holds promise as a treatment for a wide range of diseases, such as cancer, cystic fibrosis, heart disease, diabetes, hemophilia and AIDS..