Malaria typically presents with nonspecific symptoms such as fever, chills, sweats, headache, and myalgia. In Western countries, almost all malaria occurs in travelers; therefore, the diagnosis may be missed if a history of travel is not elicited., In 2022, Comoros and Sao Tome and Principe reported zero malaria deaths for the first time. And that same year, Botswana, Eritrea and Eswatini all reported fewer than 10 malaria deaths. Cabo Verde has reported zero malaria deaths since 2018 and has requested an oficial certification of malaria elimination from WHO (decision expected in early 2024)., Learn the history, theme, and significance of World Malaria Day, 25 April 2025. Discover why malaria prevention remains crucial for global health., According to WHO, the disease caused 597,000 deaths in 2023, with the African continent accounting for 95 per cent of global deaths. Children under five made up 76 per cent of these fatalities. The spread of this new mosquito species may force Kenya and its neighbours to revise current malaria control strategies., Historical Development of Malaria Vaccines The quest for a malaria vaccine has been one of the most complex and enduring challenges in tropical medicine. 100, 101 Unlike many other infectious diseases, malaria is caused by a eukaryotic parasite with a highly complex life cycle involving mosquito and human hosts. 102 This life complexity, besides the ability of Plasmodium to evade the human , .