With the exception of spironolactone (Aldactone) and triamterene, diuretics can be problematic for atrial fibrillation patients. The reason is that most diuretics are well-known to cause mineral depletion in the body. Depletion of those key minerals, especially potassium and magnesium, is often enough to trigger atrial fibrillation. 2. NSAIDs, Many widely used medications may cause or exacerbate a variety of arrhythmias. Numerous antiarrhythmic agents, antimicrobial drugs, psychotropic medications, and methadone, as well as a growing list of drugs from other therapeutic classes (neurological drugs, anticancer agents, and many others), can prolong the QT interval and provoke torsades de pointes. Perhaps less familiar to clinicians is , Atrial fibrillation/flutter is reported as a side effect among people who take Valium (diazepam), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lasix, and have Multiple myeloma. The phase IV clinical study analyzes which people have Atrial fibrillation/flutter when taking Valium., The atrial and ventricular effective refractory periods remained unchanged after the administration of diazepam. Six of the eight patients who showed dual AV nodal refractory period curves in the control study did not demonstrate them after diazepam administration by increasing the atrial or AV node effective refractory period., Your afib questions were answered by Cleveland Clinic atrial fibrillation experts Dr. David Van Wagoner, Dr. Walid Saliba, and Dr. Sergio Pinski. Diazepam has been shown to improve heart rate variability and reduce sympathetic nerve activity. T. Ikeda, M. Doi, K. Morita, and K. Ikeda. Effects of midazolam and diazepam as premedication on , The phase IV clinical study analyzes which people have Atrial fibrillation/flutter when taking Diazepam, including time on the drug, (if applicable) gender, age, co-used drugs and more. It is created by eHealthMe based on reports of 105,904 people who have side effects when taking Diazepam from the FDA, and is updated regularly..