According to Russell Jay Hendel, differentiated instruction (DI) boosts students' academic performance and satisfaction with learning, especially when teachers receive proper training beforehand. However, the vast amount of DI literature can overwhelm many educators, making it difficult for them to implement DI effectively for students with different learning styles. He proposes a transdisciplinary approach to bridge the gap between theory and the challenging practical application of DI. 1) Drawing from architecture, the concept of universal design is introduced, advocating for buildings to be initially constructed to accommodate everyone rather than trying to make adjustments after construction, which can be expensive and inefficient. 2) Neuroscience suggests that higher cognitive brain functions, like executive function, can be effectively addressed through a multi-modal approach, emphasizing the need for inclusive teaching methods that cater to various learning preferences. 3) Industrial psychology highlights the importance of goal-setting and breaking down complex tasks into manageable steps, promoting clear, achievable, and challenging objectives. 4) Combining goal-setting with the concept of self-efficacy from social psychology, utilizing software technology with differentiated difficulty levels is advocated, enabling students to assess and improve their learning through self-regulation. This transdisciplinary approach proposes several innovative strategies for DI, which it hopes other educators and researchers will explore further []. Drawing from the concept of universal design means creating learning environments and educational materials that are accessible and inclusive for all students, regardless of their abilities or backgrounds. This approach recognizes that students have diverse needs, learning styles, and abilities and aims to design educational experiences that cater to this diversity from the outset. For example, in the design of classrooms, universal design principles might involve: Ensuring classrooms are spacious and well-lit to accommodate students with mobility issues or visual impairments. We provide flexible seating arrangements for different learning preferences and physical needs. They are incorporating technology and multimedia resources that students with various learning styles and abilities can access. They offer materials in multiple formats (e.g., digital, audio, tactile) to accommodate different learning needs and preferences. Implementing inclusive teaching strategies that engage all students and provide opportunities for active participation., Each student has unique preferences and strengths when it comes to learning, and understanding these styles allows educators to tailor their teaching methods for more effective learning outcomes., Review Highlights • By adapting instruction, content, and assessment to meet the needs of various learners, differentiation in education improves student engagement and accomplishment. • Differentiation addresses students' varied learning styles and strengths by utilizing the many intelligences theory to customize instruction, content, and evaluation. • The study underscores the .