Granulomatosis with Polyangiitis is a disease involving granulomatous inflammation, necrosis and vasculitis that most frequently targets the upper respiratory tract, lower respiratory tract, and kidneys., Granulomatosis with polyangiitis (also termed Wegener's) is a rare disease that results in inflamed blood vessels (vasculitis or polyangiitis) and nodules of inflammatory cells (granulomas) in affected tissues. The most common signs and symptoms are. hearing loss., Granulomatosis with Polyangiitis (Formerly Wegener’s Granulomatosis) Strawberry gingivitis Exudates on the edge of the cornea Severe scleritis Collapse in the bridge of the nose Swelling and inflammation pre-diagnosis of GPA Skin lesion in GPA Subglottic stenosis in GPA Untreated GPA eroding through the skin between the nose and the right eye, Granulomatosis with polyangiitis (GPA), formerly known as Wegener granulomatosis, is a rare multisystem autoimmune disease of unknown etiology. Its hallmark features include necrotizing, Ear, nose and throat manifestations of granulomatosis with polyangiitis include: Subglottic stenosis (narrowing of the airway), presenting with hoarseness, stridor (noisy breathing) or life-threatening airway obstruction., Granulomatosis with polyangiitis (GPA) is a rare condition where blood vessels become inflamed, mainly in the ears, nose, sinuses, kidneys and lungs. It can be serious if not treated but medicines can help manage the symptoms. GPA was previously called Wegener's granulomatosis..