Persistent or severe symptoms warrant seeking guidance from a healthcare professional. They may prescribe medications, like PPIs, if your symptoms don't improve. For short-term relief, taking acid reflux medications daily is generally safe for a few weeks at a time. For example, you can take PPIs or histamine antagonists daily for up to two weeks., All of these over-the-counter medicines, to a varying degree, can relieve the symptoms of heartburn. If you have more severe heartburn symptoms that these medications don't relieve, or if you've , Get heartburn relief fast with top products from CVS. Browse our selection of heartburn medicine and get FREE shipping on most orders., TREATS FREQUENT HEARTBURN: Heartburn medicine for those who experience heartburn flare ups 2+ times a week ; With 1 PRILOSEC OTC PILL EACH MORNING, 24 HOURS. ZERO HEARTBURN.* Unlike antacids which last only 1-3 hours ; PREVENT EXCESS ACID PRODUCTION for heartburn relief that lasts for 24 HOURS.* Starts working on DAY 1*, Over-the-counter (OTC) medications, such as antacids and H2 blockers, can help treat heartburn. People can also try home remedies, including ginger and apple cider vinegar. If symptoms persist, a , Gastroesophageal Reflux Disease (GERD) affects millions of people worldwide, causing discomfort and potentially serious complications if left untreated. For many individuals suffering from GERD, over-the-counter (OTC) medicines can provide significant relief from symptoms such as heartburn, regurgitation, and chest pain..