Crohn's Disease Treatment: Surgery About 40 to 60 percent of patients with ileal Crohn's disease (Crohn's disease in a certain part of your small intestine) need surgery during the first 10 years of symptoms. If you develop an abscess or perforation, you may need surgery earlier., Medication Options for Crohn’s Disease Successful medical treatment allows your intestinal tissue to heal and it helps relieve symptoms such as fever, diarrhea, and abdominal pain. There are several groups of drugs used to treat Crohn’s disease., Crohn’s disease causes inflammation in your digestive system. Learn more about symptoms, causes, risk factors, triggers & treatment options., , , .