The efficacy of ivermectin in preventing hospitalization or extended observation in an emergency setting among outpatients with acutely symptomatic coronavirus disease 2019 (Covid-19), the, Ivermectin is approved by the U.S. Food and Drug Administration to treat certain kinds of parasites and neglected tropical diseases, including scabies and parasitic worms. It is not approved to, Ivermectin is likely to be an equitable, acceptable, and feasible global intervention against COVID-19. Health professionals should strongly consider its use, in both treatment and prophylaxis. ACKNOWLEDGMENTS. This work was inspired by the prior literature review of Dr Pierre Kory., New research led by the University of Oxford has concluded that the antiparasitic drug ivermectin does not provide clinically meaningful benefits for treating COVID-19 in a largely vaccinated population., Today JAMA publishes a new trial of ivermectin treatment for mild to moderate COVID-19 that addresses the possibility that the existing literature may have missed the efficacy of ivermectin because the previously tested dose (approximately 400 μg/kg daily for 3 days) was insufficient. 5 At a higher treatment dose (600 μg/kg daily) and longer , The current evidence on the use of ivermectin to treat COVID-19 patients is inconclusive. Until more data is available, WHO recommends that the drug only be used within clinical trials. This recommendation, which applies to patients with COVID-19 of any disease severity, is now part of WHO’s guidelines on COVID-19 treatments..