Metastatic castration-resistant prostate cancer presents treatment challenges, including the side effects of chemotherapy. Mayo Clinic researchers find that lutetium-177 prolongs radiographic progression-free survival in patients yet to receive taxane chemotherapy., Lutetium-177 PSMA therapy is an innovative molecular therapy used to treat advanced prostate cancer, also known as metastatic prostate cancer (cancer that has spread from the prostate to other parts of the body)., ASCO recently published a rapid recommendation systemic therapy update on lutetium-177 (177 Lu)-PSMA-617 (vipivotide tetraxetan) for metastatic castration-resistant prostate cancer. 1 This therapy delivers targeted beta-particle radiation to prostate-specific membrane antigen (PSMA)–expressing tumor cells leading to DNA damage and potential , FDA approval of Pluvicto (lutetium Lu 177 vipivotide tetraxetan) for the treatment of adult patients with prostate-specific membrane antigen-positive metastatic castration-resistant prostate cancer who have been treated with androgen receptor pathway inhibition and taxane-based chemotherapy., The suitability of [177 Lu]Lu-PSMA-617 for the treatment of prostate cancer patients was demonstrated in numerous clinical trials, leading to its FDA approval, its marketing authorization in Great Britain, and the soon-expected approval by the EMA for use in Europe., On March 23, 2022, the Food and Drug Administration approved Pluvicto (lutetium Lu 177 vipivotide tetraxetan, Advanced Accelerator Applications USA, Inc., a Novartis company) for the treatment of.