формирование культуры общения детей в детских садах
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формирование культуры общения детей в детских садах, Bone Pain Due to White Blood Cell Growth Factors, Why do you take Claritin with Neulasta? - Drugs.com, Bone pain from Neulasta (pegfilgrastim) | Mayo Clinic Connect, Effect of Loratadine for Pegfilgrastim-Induced Bone Pain, Severe pegfilgrastim-induced bone pain completely alleviated with , Bone Pain - ChemoExperts, Randomized phase II study of loratadine for the prevention of bone pain .
Treatment options for bone pain caused by white blood cell growth factors include antihistamines, nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, and opioids for severe pain. There is relatively limited clinical data studying the use of loratadine and other antihistamines for bone pain in this setting. There are some case reports on the use of loratadine, astemizole (no longer available in the United States), and hydroxyzine (Atarax) to manage bone pain due to white blood cell growth factors. In the report on the use of loratadine, a patient with severe bone pain thought to be due to pegfilgrastim took loratadine 10 mg daily starting the day prior to chemotherapy through 5 days following chemotherapy. This patient experienced a resolution in her pain and was able to continue receiving pegfilgrastim with her chemotherapy., We sometimes use loratadine (Claritin) to treat bone pain in patients receiving white blood cell growth factors. How does this work? White blood cell growth factors are used in the prevention, The reason why Claritin (loratadine) is taken with Neulasta (pegfilgrastim) is to reduce bone pain, which is a very common side effect of Neulasta. When patients are undergoing chemotherapy it often causes a decrease in neutrophils levels (which is a type of white blood cell that fights infection) and this increases the risk of infections..
The Claritin was a separate approach specific for bone pain. The first time I used it I experienced about 75% less bone pain. Considered myself extremely fortunate., We found that women perceived that loratadine was more effective for controlling pegfilgrastim-induced bone pain than NSAIDs, but not better than acetaminophen. Because 65% of women were pain free, we do not know if loratadine was truly effective in prevention or if the women would have been pain free without the use of loratadine., We present the first case report in which loratadine prophylaxis completely alleviated NSAID-resistant severe pain secondary to pegfilgrastim. The result showed that loratadine may be a promising option for severe, resistant pegfilgrastim-induced bone pain. Further clinical studies are warranted and ongoing., In patients with bone pain from filgrastim or pegfilgrastim, use of antihistamines such as loratadine (Claritin®) or cetirizine (Zyrtec®) can help alleviate bone pain in some cases., Pegfilgrastim is a 20-kilodalton polyethylene glycol carrier of filgrastim that is covalently bound at the N-terminal residue. Randomized trials have demonstrated that a single dose of pegfilgrastim offers neutrophil support comparable to multiple once-daily doses of filgrastim (1, 2)., Prophylaxis for FN should include granulocyte colony stimulating factor (G-CSF), given 24 hours following each chemotherapy cycle.² Available G-CSF formulations include filgrastim (Neupogen) and tbo-filgrastim (Granix), which are given in daily injections for up to 14 days, and the long-acting pegfilgrastim (Neulasta), which is given in a .