формирование поведения животных в норме и патологии
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формирование поведения животных в норме и патологии, Cancer Gene Therapy - Nature, The Current Status of Gene Therapy for the Treatment of Cancer, What is Gene Therapy? - OncoLink, How is Gene Therapy Being Used to Treat Cancer? | Dana-Farber , Gene therapy - Mayo Clinic, , .
Platelets, traditionally known for their role in hemostasis, are now recognized as key modulators of oncological processes, influencing tumor growth and metastasis through interactions with the tumor microenvironment. Recent studies reveal that platelet activation contributes to T-cell exhaustion by releasing thromboxane A2 (TXA2), which binds to the TBXA2R receptor and activates ARHGEF1, a guanine nucleotide exchange factor (GEF), leading to the suppression of T-cell function. This editorial explores the potential of repurposing anti-platelet drugs, such as aspirin, to counteract these effects. Aspirin, by inhibiting cyclooxygenase enzymes essential for TXA2 synthesis, can enhance T-cell activity in metastatic contexts, thereby improving immune surveillance and response. We advocate for further investigation into the thromboxane pathway’s impact on T-cell functionality and the development of aspirin-based therapeutic strategies to combat cancer metastasis., We advocate for further investigation into the thromboxane pathway’s impact on T-cell functionality and the development of aspirin-based therapeutic strategies to combat cancer metastasis., Finally, this review summarizes gene therapy medicines approved to treat cancer in detail, including names, indications, vectors, and mode of gene therapy. Gene therapy becomes an alternative to an existing management for different diseases..
Researchers are testing ways to use gene therapy to treat cancer. Gene therapy may be used to: Replace missing or non-working genes. For example, p53 is a gene called a "tumor suppressor gene." Tumor suppressor genes prevent or stop tumors from forming., There are several approved gene therapies for non-cancerous diseases caused by a single gene mutation. In 2023, the U.S. Food and Drug Administration (FDA) approved CRISPR-based gene therapy to correct the gene abnormality that causes sickle cell disease., Gene therapy aims to fix a faulty gene or replace it with a healthy gene to try to cure disease or make the body better able to fight disease. It holds promise as a treatment for a wide range of diseases, such as cancer, cystic fibrosis, heart disease, diabetes, hemophilia and AIDS., , , .