Persistent definition: persisting, especially in spite of opposition, obstacles, discouragement, etc.; persevering.. See examples of PERSISTENT used in a sentence., Define persistent. persistent synonyms, persistent pronunciation, persistent translation, English dictionary definition of persistent. adj. 1. Refusing to give up or let go; persevering obstinately., Definition of persistent adjective in Oxford Advanced Learner's Dictionary. Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more., Something that is persistent continues to exist or happen for a long time; used especially about bad or undesirable states or situations. Her position as national leader has been weakened by persistent fears of another coup attempt. His cough grew more persistent until it never stopped., persistent, adj. meanings, etymology, pronunciation and more in the Oxford English Dictionary, If something is persistent, it just won't stop. If you're persistent in your suggestions for a trip to Mexico, maybe your parents will eventually give in and take you there..