Prolia (denosumab) is a prescription drug that’s used to treat osteoporosis and bone loss. Prolia comes as a liquid solution that’s given as an injection under the skin., Denosumab (Prolia, Jubbonti, Stoboclo) is commonly used to treat osteoporosis, a condition in which the bones are thinner, weaker, and more prone to breakage. Denosumab may be prescribed for, Find the cost of Prolia® depending on your insurance coverage, as well as additional patient support through the Bone Matters® program. See full prescribing & safety info., What Is Prolia? Prolia (denosumab) is a monoclonal antibody used to treat bone loss (osteoporosis) in women who are at high risk for bone fracture after menopause. What Are Side Effects of Prolia? Prolia may cause serious side effects including: new or unusual pain in your thigh, hip or groin, severe pain in joints, muscles, or bones, dry skin,, DENOSUMAB (den oh sue mab) slows bone breakdown. Prolia is used to treat osteoporosis in women after menopause and in men, and in people who are taking corticosteroids for 6 months or more., Prolia® is indicated for the treatment of postmenopausal women with osteoporosis at high risk for fracture, defined as a history of osteoporotic fracture, or multiple risk factors for fracture; or patients who have failed or are intolerant to other available osteoporosis therapy..