Sparsentan (Filspari) is a medication used to reduce protein excretion in urine (proteinuria) in adults with primary immunoglobulin A nephropathy (IgAN), a progressive kidney disease. Do not take if pregnant or breastfeeding. Common side effects of sparsentan include swelling of extremities (peripheral edema), low blood pressure (hypotension), drop in blood pressure when standing up from , The FDA granted full approval to Filspari, a daily oral, non-immunosuppressive medication, to slow kidney function decline in adults with primary IgA nephropathy, according to an industry press , FDA grants full approval to Filspari to slow kidney function decline in adults with primary IgA nephropathy at risk for disease progression., Sparsentan (Filspari) is used to treat primary immunoglobulin A nephropathy (IgAN) to maintain kidney function and reduce protein in urine (proteinuria). Includes sparsentan side effects, interactions, and indications., Filspari was approved for reducing proteinuria in people with primary IgAN based on preliminary (or interim) results from the PROTECT trial, which involved 134 medical practices in 18 countries., FILSPARI is the only oral, once-daily, non-immunosuppressive medication that directly targets glomerular injury in the kidney by blocking two critical pathways of IgAN disease progression (endothelin-1 and angiotensin II)..