Immunotherapy for bladder cancer is primarily administered through intravenous (IV) infusions and intravesical therapy. IV infusions, used for drugs like pembrolizumab, deliver medication directly into the bloodstream. These sessions typically last 30 minutes to a few hours and are scheduled every 2 to 3 weeks based on the treatment plan., Keywords: bladder cancer, immunotherapy, checkpoint inhibitor. 1. Introduction. Bladder cancer (BC) is the sixth most commonly diagnosed cancer in men worldwide and the 10th when considering men and women together . The worldwide age-standardized incidence rate (per 100,000 person/years) is 9.6 for men and 2.4 for women . In Europe, the overall , Immunotherapy uses the immune system to attack cancer cells, in much the same way that it attacks bacteria or viruses. We offer bacillus Calmette-Guérin (BCG) therapy, a more recent advance in cancer treatment.. This type of immunotherapy is used after surgery for bladder cancer that has not grown into muscle (non-muscle invasive)., Immunotherapy for treatment-resistant non-muscle-invasive bladder cancer. Immunotherapy, a drug treatment that helps your immune system fight cancer, is sometimes used to prevent the recurrence of non-muscle-invasive bladder cancer, especially when bladder preservation is a priority., The FDA has approved nogapendekin alfa inbakicept-pmln, which stimulates immune cells to fight bladder cancer. The U.S. Food and Drug Administration (FDA) has approved nogapendekin alfa inbakicept-pmln (Anktiva) in combination with Bacillus Calmette-Guérin (BCG), for the treatment of certain adult patients with non-muscle invasive bladder cancer (NMIBC) that has not responded to BCG alone., Intravesical immunotherapy is also used to treat bladder cancer that comes back only in the inner lining of the bladder. Immune checkpoint inhibitors The immune system normally stops itself from attacking normal cells in the body by using specific proteins called checkpoints, which are made by some immune system cells..