What works fastest for heartburn? Over-the-counter (OTC) medications are available when you need quick relief. Explore OTC heartburn medications, including Tums and Rolaids, with GoodRx., Prescription Medication for Acid Reflux H2 blockers. In prescription form (usually higher doses than the over-the-counter versions), H2 blockers can generally relieve heartburn and treat reflux , About this item 50-count of Maximum Strength Pepcid AC All-Day Heartburn Relief Tablets with famotidine, for the prevention and relief of heartburn due to acid indigestion and sour stomach Just 1 tablet of the extra strength heartburn medicine controls acid all day or all night (based on 9-hour acid control studies during the day and 12-hour acid control studies during the night. Acid control , PPI medication that's available in 15 milligram formula. Delayed-release capsules are easy to swallow and provide lasting relief for frequent heartburn as well as symptoms of GERD. Reasonable price point. Only recommend for 14 days of use, at which time you should consult your medical provider if symptoms persist. May take several days to work., Verdict Choosing the right over-the-counter medication can be daunting, especially when dealing with persistent heartburn or acid reflux. This article has provided a comprehensive overview of the leading contenders in the market, helping you navigate the complexities of choosing among the available best OTC proton pump inhibitors., The length of time that the best over-the-counter heartburn medicine provides relief may vary depending on the individual and the severity of their symptoms. However, most over-the-counter heartburn medications are designed to provide relief for a few hours, ranging from 2 to 12 hours..