Among the diverse plant LysM proteins, two groups of LysMe proteins showcase a conserved structure characterized by an N-terminal signal peptide and a single LysM domain at the C-terminal, which is akin to fungal LysM effectors, such as Slp1 (Secreted LysM Protein 1) from M. oryzae (Zhang et al., 2009; Mentlak et al., 2012)., LysM-containing proteins have also been reported to be involved in the innate immunity of some invertebrates, red swamp crayfish (Procambarus clarkia) and kuruma shrimp (Marsupenaeus japonicas), although the defense mechanism is still unclear.9,10 Interestingly, in plants, structurally related LysM receptors are also required for the symbioses , LysM-containing proteins have also been reported to be involved in the innate immunity of some invertebrates, red swamp crayfish (Procambarus clarkia) and kuruma shrimp (Marsupenaeus japonicas), although the defense mechanism is still unclear.9,10 Interestingly, in plants, structurally related LysM receptors are also required for the symbioses , A LysM motif-containing plasma membrane protein, CEBiP (chitin oligosaccharide elicitor-binding protein), participates in the perception of chitin oligosaccharides in rice (4). The CEBiP has two LysM motifs in the extracellular domain and lacks the intracellular kinase domain that is required for signal transduc-tion., Recognition of Nod factors by the LysM domain-containing receptors NFR1 and NFR5 (purple) and the leucine-rich repeat (LRR) domain-containing receptor SYMRK (green domain) is probably assisted by other unknown recognition factors (indicated with ‘X’)., .