CI = confidence interval; GI = gastrointestinal; NANSAID = non aspirin nonsteroidal anti-inflammatory drugs; NSAID = nonsteroidal anti-inflammatory drug; UGI = upper gastrointestinal.* Odds ratios were relative to non-use of any NANSAID or aspirin, and were adjusted for use of aspirin, use of anticoagulants, smoking, and history of UGI problems.† Ibuprofen showed the lowest odds ratio (OR = 1.7; 95% CI: 1.1, 2.5), followed by diclofenac (4.9; 95% CI: 3.3, 7.1), indomethacin (6.0; 95% CI: 3.6, 10.0), naproxen (9.1; 95% CI: 6.0 13.7), piroxicam (13.1; 95% CI: 7.9 21.8) and ketoprofen (34.9; 95% CI: 12.7, 96.5). The meta-analysis was carried out in hospitals in Catalonia, England, Scotland, and Sweden. There were 2,472 cases of UGI bleeding and 5,877 controls that were studied. , Designed with dual-layer technology for an extended 12-hour release, Advil 12 Hour Tablets provide fast acting, long-lasting pain relief. In addition to providing relief from backaches and muscle and joint pain, Advil 12 Hour Tablets relieve pain from inflammation associated with arthritis or physical overexertion. Advil 12 Hour Tablets also relieve aches and pains due to the common cold and , Advil 12 Hour is an ideal option for Ellen’s tension headaches. Ellen works long hours as a middle school teacher and describes herself as ‘stressed out’ yet committed to her students. She wants to avoid missing teaching days and looking for effective relief that will work fast and last..