Amoxicillin/clavulanate is a penicillin-type combination antibiotic made up of amoxicillin (the active, antibiotic part) and clavulanate potassium (which boosts the effectiveness of amoxicillin). It may be used to treat infections caused by certain susceptible bacteria., Guide to Amoxicillin-clavulanate (Augmentin®) Dosing Dosing for patients ≥ 3 months old with normal renal function Step 2: How to dose Note: Dosing based on amoxicillin component, This calculator will guide you towards the correct amoxicillin-clavulanate formulation to prescribe based on the patient's age, weight, and disease. NOTE: This is not meant to be used in place of a real-life pharmacist. Please always confirm with them if you have doubts or questions about proper amoxicillin-clavulanate formulation selection., When prescribing amox/clav, the first decision is whether the amoxicillin should be dosed at standard dose (30-50 mg/kg/day) or high dose (80-90 mg/kg/day). High dose amoxicillin should be used for any infection where Streptococcus pneumoniae coverage is needed (e.g. AOM, CAP, sinusitis)., The first ratio for an amoxicillin-clavulanic acid combination was set at 4:1 due to clavulanic acid's high affinity for β-lactamases; ratios of 2:1, 7:1, 14:1 and 16:1 are currently available in various regions., First, to achieve sufficient amoxicillin and high clavulanic acid exposure, the optimal regimen is to administer narrower ratio amoxicillin–clavulanic acid (typically 4:1, as the 2:1 combination is not available in many regions) in a three times daily regimen..