“In the past, our treatment choices were systemic immunosuppressants, which risked many side effects, or phototherapy, which inflicts a major time burden on adolescents and their families. Injected biologics are now first-line systemic therapy, targeting the activated pathway recognized to cause atopic dermatitis. However, giving the painful injection to adolescents every two weeks can be challenging and sometimes the biologic therapy is not sufficiently effective,” said Paller, who is also a professor of in the Division of and director of the . , Long-term treatment with the drug upadacitinib significantly improved symptoms and quality of life compared to placebo in adolescents with moderate to severe atopic dermatitis after 76 weeks with strong evidence of safety, according to a recent Northwestern Medicine analysis of three international, randomized clinical trials., Most side effects were mild or moderate; the most common were upper respiratory tract infection (for example, common cold), dermatitis atopic (worsening of AD), injection-site reaction, asthma, and headache. Conclusion ECZTRA 6 was the first trial to demonstrate that tralokinumab improves AD and is well tolerated in adolescent patients..