The safety and effectiveness of XYWAV for the treatment of cataplexy or excessive daytime sleepiness in pediatric patients 7 years of age and older with narcolepsy have been established., Xywav is the only low-sodium oxybate approved by the U.S. Food and Drug Administration for the treatment of cataplexy or excessive daytime sleepiness (EDS) in patients 7 years of age and older with narcolepsy and for adults with idiopathic hypersomnia. The Xywav label recommends a nightly dose of 6-9 grams per night., Xywav was originally FDA-approved in 2002 to treat excessive daytime sleepiness (EDS) and cataplexy (sudden muscle weakness triggered by strong emotions) in people at least 7 years old who have narcolepsy. It became FDA-approved for IH in adults in 2021. Xywav is unique because it’s the only medication that’s specifically FDA-approved for IH., Notably, these DUET (Develop hypersomnia Understanding by Evaluating low-sodium oxybate Treatment) data show prospective improvements on excessive daytime sleepiness, as well as key polysomnography outcomes of sleep disruption, among adults with narcolepsy treated with Xywav (calcium, magnesium, potassium, and sodium oxybates) oral solution., XYWAV is the first and only FDA-approved medication to treat IH in adults. XYWAV has been studied across multiple symptoms of IH, such as excessive daytime sleepiness, sleep inertia, cognitive impairment, and long sleep time., Management of excessive daytime sleepiness (EDS) includes both pharmacologic and nonpharmacologic options, depending on its underlying cause..