Pan et al. (2011) found that a high magnesium diet significantly increased magnesium concentrations in plasma and nerve tissue, which improved neurobehavioural and electrophysiological functions and reduced the deposition of inflammatory cells (such as macrophages) and inflammatory cytokines expression., Deficient magnesium disrupts nerve function through multiple pathways contributing to neuropathy. One major effect is calcium homeostasis dysregulation, as magnesium acts as a natural calcium channel blocker., Studies have shown that taking magnesium supplements can improve neuropathy symptoms, including pain, numbness, and tingling. It is crucial to consult a healthcare professional before taking magnesium supplements, especially for individuals with pre-existing medical conditions., Low levels of magnesium in the body can contribute to nerve damage and exacerbate symptoms of peripheral neuropathy. Research has shown a link between magnesium deficiency and an increased risk of developing nerve-related conditions., Studies in animals and in patients have suggested that magnesium (Mg), a physiological blocker of N-methyl-D-aspartate receptor, could have an antinociceptive effect in painful situations. This randomised, double-blind, controlled trial in two parallel groups aims at studying oral Mg effects in patients with neuropathic pain., .