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Tacrolimus (Protopic): How to Use & Side EffectsLocations:||||||Home/Health Library/Drugs, Devices & Supplements/Tacrolimus ointmentAdvertisementAdvertisementTacrolimus ointmentTacrolimus is a medicated ointment that treats eczema. Eczema causes dry and itchy patches of skin on your body. You can rub this ointment onto your affected skin gently. Make sure you wash your hands before and after using the medication. The brand name of tacrolimus is Protopic®.AdvertisementCleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. PolicyWhat is this medication?TACROLIMUS (ta KROE li mus) is used on the skin to treat eczema.AdvertisementCleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. PolicyThis medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.COMMON BRAND NAME(S): ProtopicWhat should I tell my care team before I take this medication?They need to know if you have any of these conditions:Cutaneous T-cell lymphomaImmune system problemsInfection especially a viral infection such as chickenpox, cold sores, or herpesLarge areas of burned or damaged skinNetherton's syndromeRecent or ongoing radiationAn unusual or allergic reaction to tacrolimus, other medications, foods, dyes, or preservativesPregnant or trying to get pregnantBreast-feedingHow should I use this medication?This medication is for external use only. Do not take by mouth. Wash your hands before and after use. If you are treating your hands, only wash your hands before use. Do not get it in your eyes. If you do, rinse your eyes with plenty of cool tap water. Use it as directed on the prescription label at the same time every day. Do not use it more often than directed. Keep taking it unless your care team tells you to stop.Apply a thin film of the medication to the affected area. Before applying this medication, the affected area should be patted dry. Do not cover the area with a dressing (bandage). You can wear normal clothing to cover the affected area. Do not bathe, shower, or swim right after applying this medication as it may wash off.AdvertisementA special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as 2 years for selected conditions, precautions do apply.Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.NOTE: This medicine is only for you. Do not share this medicine with others.What if I miss a dose?If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.What may interact with this medication?alcoholic beverages or medicines containing high percentages of alcoholcalcium channel blockers like diltiazem, nifedipine, nimodipine, nisoldipinecertain medicines used to treat fungal infections like itraconazole, ketoconazole, and fluconazolecimetidineerythromycinvaccinesThis list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.What should I watch for while using this medication?Improvements to your skin may occur after the first few weeks of treatment. Even though your skin looks better, it is important to keep using the ointment as instructed by your health care provider. Tell your health care professional if your condition does not get better within the first few weeks of treatment or if it gets worse.This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.While you are using this medicine, drinking alcohol may cause the skin or face to become flushed or red and feel hot. Let your health care provider know if you notice such reactions, especially if they bother you.What side effects may I notice from receiving this medication?Side effects that you should report to your doctor or health care professional as soon as possible:chickenpox infectioncold sores or shinglesextreme tirednessskin bleeding or change in your skin's appearance (color, change in a mole or freckle, new growth)skin infection or infection of hair folliclesswollen glandsSide effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):Advertisementheadacheincreased sensitivity of the skin to hot or cold temperaturesirritation at the site or sites where you apply this medicine including stinging, soreness, a burning feeling, tingling, or itchingmuscle painsnauseaThis list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.Where should I keep my medication?Keep out of reach of children.Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.AdvertisementCopyright ©2025 Elsevier Inc. All Rights Reserved..Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.AdvertisementAdvertisementAdCall Appointment Center Questions Rendered: Fri Jul 04 2025 14:51:34 GMT+0000 (Coordinated Universal Time)ActionsBlog, News & AppsAbout Cleveland ClinicSite Information & Policies9500 Euclid Avenue, Cleveland, Ohio 44195 | 800.223.2273 | © 2025 Cleveland Clinic. All Rights Reserved., Use it as directed on the prescription label at the same time every day. Do not use it more often than directed. Keep taking it unless your care team tells you to stop. Apply a thin film of the medication to the affected area. Before applying this medication, the affected area should be patted dry. Do not cover the area with a dressing (bandage)., At the end of the 4 weeks, average eczema symptoms were significantly reduced, with no reports of serious adverse events. The researchers concluded that tacrolimus is effective and safe for.
It cleared up within 2 and a half to 3 weeks (2x daily) for me—I just tried to taper down to once daily at the 3week mark and its creeping back though, so I’m switching back to 2x daily for a short burst before trying to go back down again., Use this medicine exactly as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may increase the chance of side effects., dose. How long does it take to work? Tacrolimus works slowly and . ay take up to 12 weeks to take effect. Unless you have severe side effects it is important to continue taking it even if you do . ot notice any change. in your symptoms. What dose do I take? The dose of tacrolimus depends on your weight a., Tacrolimus ointment generally takes about 1 to 2 weeks to show noticeable improvement in eczema symptoms. Individual responses may vary based on factors such as skin type, severity of the condition, and adherence to application guidelines., HOW LONG DOES IT TAKE FOR PROTOPIC TO WORK? Protopic can provide rapid clearing of your condition. When using Protopic you can start to notice dramatic improvement in about 1 - 3 weeks. Most people start to notice that their skin starts to heal after the first few weeks of treatment and continues to improve as they keep using the ointment., Take tacrolimus at the same time (s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tacrolimus exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor..