Ruth Link-Gelles, PhD1; Sean Chickery, DHSc2; Alexander Webber, MPH1; Toan C. Ong, PhD3; Elizabeth A.K. Rowley, DrPH2; Malini B. DeSilva, MD4; Kristin Dascomb, MD, PhD5; Stephanie A. Irving, MHS6; Nicola P. Klein, MD, PhD7; Shaun J. Grannis, MD8,9; Michelle A. Barron3; Sarah E. Reese, PhD2; Charlene McEvoy, MD4; Tamara Sheffield, MD5; Allison L. Naleway, PhD6; Ousseny Zerbo, PhD7; Colin Rogerson, MD9,10; Wesley H. Self, MD11; Yuwei Zhu, MD11; Adam S. Lauring, MD, PhD12; Emily T. Martin, PhD12; Ithan D. Peltan, MD13,14; Adit A. Ginde, MD15; Nicholas M. Mohr, MD16; Kevin W. Gibbs, MD17; David N. Hager, MD, PhD18; Matthew E. Prekker, MD19; Amira Mohamed, MD20; Nicholas Johnson, MD21; Jay S. Steingrub, MD22; Akram Khan, MBBS23; Jamie R. Felzer, MD24; Abhijit Duggal, MD25; Jennifer G. Wilson, MD26; Nida Qadir, MD27; Christopher Mallow, MD28; Jennie H. Kwon, DO29; Cristie Columbus, MD30,31; Ivana A. Vaughn, PhD32; Basmah Safdar, MD33; Jarrod M. Mosier, MD34; Estelle S. Harris, MD14; James D. Chappell, MD, PhD11; Natasha Halasa, MD11; Cassandra Johnson, MS11; Karthik Natarajan, PhD35,36; Nathaniel M. Lewis, PhD37; Sascha Ellington, PhD37; Emily L. Reeves, MPH37; Jennifer DeCuir, MD, PhD37; Meredith McMorrow, MD1; Clinton R. Paden, PhD1; Amanda B. Payne, PhD1; Fatimah S. Dawood, MD1; Diya Surie, MD1; CDC COVID-19 Vaccine Effectiveness Collaborators (View author affiliations), As has been the case for the past 3 years in the US, this fall’s updated COVID-19 vaccines will target SARS-CoV-2 variants that will have virtually disappeared by the time the shots are available—sometime by mid-September., The new updated COVID-19 vaccines for 2025-2026 will be available in the fall. Here are answers to some of the most common questions about the vaccine..