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постдипломное педагогическое образование математика, Randomized control trial of moderate dose vitamin D alters microbiota , SUPPLEMENTARY MATERIALS Title, The Association between Vitamin D and Gut Microbiota: A Systematic , Randomized control trial of moderate dose vitamin D alters microbiota , Enhance Gut Microbiome with Vitamin D - Thrivous®, The Effect of Various Doses of Oral Vitamin D, The Effect of Various Doses of Oral Vitamin D - PubMed.
Vitamin D3 induces temporal changes of individual metabolites across placebo and treatment groups. (A) PRC was used separately to obtain the degree of contribution of each metabolite in both groups toward the overall change. These were standardized for each group and cross-compared by plotting the percent contribution of each metabolite obtained for PRC model, across placebo (x-axis: percentage) and treatment (y-axis: percentage) groups. Metabolites identified through RP and HILIC columns were analyzed separately and presented in respective plots. Each circle represents an individual metabolite, while green color circles represent annotated metabolites. Line of equality is used as the baseline for no change between two groups. The perpendicular distance from the central line depicts the degree of relative variation for each metabolite and the sample positioning attests to the directionality of the change, as per the quadrants highlighted. Each subplot shows the histogram of absolute perpendicular distances of annotated metabolites where the largest two bins were used for subsequent pathway explorations. (B) Differential microbe-metabolite interactions between placebo and the treatment groups. In each panel, circles represent microbes, triangles represent metabolites, and a connecting line attests to the interaction of Pearson’s correlation of 75% or more between the connected microbe and metabolite. Panels B_A and B_B show the DyNet rewiring between top correlated microbe-metabolite networks of individual placebo and treatment groups, which are shown in Panels B_C and B_D respectively. In panels B_A, B_C, and B_D, nodes/edges are colored based on their unique and shared nature as depicted in the figure legend. Panel B_A colors the rewired network based on the origin of the network, which shows that the majority of the nodes have been shared (86%: blue), while only a small number of connections are common between two individual networks (0.17%: gray). Panel B_B recolors the same DyNet rewiring, based on the degree of node rewiring, which further highlights the limited number of intact edges between two networks. This observation highlights that while these top correlated members in each group are mostly the same (86%), their interactions are overwhelmingly different between the groups (99.8%, panel B_B), suggesting differential metabolic programming due to vitamin D treatment., We conducted a double-blind, randomized, placebo-controlled trial to identify the acute and long-term microbiota structural and metabolite changes that occur in response to a moderate dose (4,000 IU) of vitamin D 3 for 12 weeks in healthy adults., Title: Randomized control trial of moderate dose vitamin D alters microbiota stability and metabolite networks in healthy adults. Authors: Madhur Wya 1, Ankan Choudhury 2, Ella Von Dohlen2, Jeffery L. Heileson1,3, Jeffrey S. Forsse1,4, Sumudu Rajakaruna5,6, Manja Zec5,6, Malak M. Tfaily5,6, and Leigh Greathouse 2,4*.
To further understand the role of VD on the modulation of the gastrointestinal microbiota, future research should be geared toward well-designed animal-based studies or larger randomized controlled trials (RCTs). Keywords: microbiome, vitamin D, supplementation, 25 (OH)D, prevention. 1. Introduction., We conducted a double-blind, randomized, placebo-controlled trial to identify the acute and long-term microbiota structural and metabolite changes that occur in response to a moderate dose (4,000 IU) of vitamin D 3 for 12 weeks in healthy adults., Vitamin D is well-known for its role in maintaining bone health, but its impact goes beyond the skeletal system. A recent study titled "Randomized control trial of moderate dose vitamin D alters microbiota stability and metabolite networks in healthy adults" explores how vitamin D affects the gut microbiome., Healthy adults who had vitamin D insufficiency/deficiency [25 (OH)D<30 ng/ml] were enrolled in a randomized, double-blinded, investigator initiated, pilot study., Increased serum 25 (OH)D was associated with increased beneficial bacteria and decreased pathogenic bacteria. A dose-dependent increase in bacteria associated with decreased inflammatory bowel disease activity was observed after vitamin D3 supplementation., Emerging evidence highlights the role of gut-vitamin D axis in the regulation of immune ageing, influencing chronic inflammation and systemic health. This review aims to explore the interplay between the gut microbiota and vitamin D in mitigating immunosenescence and preventing against chronic inflammation and age-related diseases..