All of the 12 participants enrolled from North America and Europe in the VX-880-101 FORWARD study had to have type 1 diabetes with impaired awareness of hypoglycemia, at least two severe , People with type 1 diabetes are dependent on a precarious balance of insulin therapy for their whole lives. If their insulin drops too low, cells are unable to make use of the sugar in their bloodstream, leading to a buildup that can damage organs., "A single infusion of a stem cell-based treatment may have cured 10 out of 12 people with the most severe form of Type 1 diabetes," reports the New York Times. "One year later, these 10 patients no longer need insulin. The other two patients need much lower doses." The experimental treatment, cal, Small trial in US of new treatment cures people with severe diabetes 2025-06-22 - Gina Kolata A single infusion of a stem cellbased treatment may have cured 10 out of 12 people with the most severe form of Type 1 diabetes. A year later, these 10 patients no longer need insulin. The other two patients need much lower doses., Shaping the future of health care. Penn Medicine’s 200-year history is marked by a legacy of monumental medical breakthroughs. Today, Penn is known for developing the first cell and gene therapies that cure cancer and reverse blindness, inventing mRNA vaccine technology that quelled the COVID-19 pandemic, discovering key insights about the immune system and health, and more., .