Application Type: “Clean the affected area first and never apply if there are any cuts, open wounds, or broken down skin,” warns Dr. Durrani. Dr. Marcus adds, “This [application] varies according to the active ingredients; it is best to stick to the directions on the label.” In general, you will apply to the affected area as you would with any other type of cream, but if you’re dealing with a patch, roll-on, or something different than a traditional cream there will likely be varying instructions. Dr. Durrani also says not to apply more than the directed amount and “if you have to use the product beyond a few days, consult with your doctor.”Key Ingredients: Common pain relief ingredients include lidocaine, capsaicin, menthol, diclofenac, and methyl salicylate, says Dr. Durrani. Menthol and capsaicin are why you’ll see many formulas touting hot and cold modalities, while anti-inflammatory properties can be attributed to diclofenac and methyl salicylate. Lidocaine, on the other hand, is for numbing, so that’s another one to look out for, too.Fragrance: Menthol has a strong scent and is included in various pain relief products, so it’s not uncommon for pain relief creams to have an intense fragrance. But, as with other topical products, there’s always a concern for irritation, especially for those with sensitive skin or allergies. If an unscented option is available, anyone averse to fragrance may find one of these your best choice. If you’ve had adverse reactions, check with your physician; they can guide you to something better suited for your needs. , Suffering from muscle aches and joint pain? We found the best pain relief creams and balms with lidocaine, capsaicin, menthol, and more to combat discomfort and offer relief, all with the expert help of an emergency medicine physician and a dermatologist., These are the best pain-relief creams you can get over the counter, including top picks for back pain, arthritis, shingles and hot and cold therapy creams..