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стандарт по истории фгос среднее полное образование, How To Treat the Patient With Antiphospholipid Antibody Syndrome Who , Triple positive profile in antiphospholipid syndrome: prognosis , Antiphospholipid syndrome - Symptoms & causes - Mayo Clinic, Anticoagulant Therapy in Patients with Antiphospholipid Syndrome, TRIPLE TROUBLE: TRIPLE POSITIVE ANTIPHOSPHOLIPID SYNDROME AND - CHEST, Diagnosis and Management of the Antiphospholipid Syndrome, Triple positive profile in antiphospholipid syndrome: prognosis .
204 patients were included in our study, 68 were triple-positive and 136 were single or double positive. 122 patients (59.8%) had primary APS. 67 patients (32.8%) had obstetrical APS, with a higher rate among triple-positive patients (45.6% vs 26.5%, p=0.010), and 170 patients (83.3%) had thrombotic APS, without difference between triple-positive and others. Thrombotic events were more often venous (56.4%) than arterial (37.7%). Triple-positive patients had more placental complications than others (17.6% vs 2.9%, p=0.001) and more non-criteria events (48.5% vs 25.7%, p=0.002). Among non-criteria events, there was a higher frequency of Sneddon syndrome in triple-positive patients (7.4% vs 0.7%, p=0.028). The relapse rate was higher in triple-positive patients than in others (63.2% vs 39,7%, p=0002). In multivariate analysis, the triple-positive profile was associated with a higher risk of relapse (HR 1.63; 95% CI 1.04 to 2.55; p=0.031)., This randomized trial compared rivaroxaban with the vitamin K antagonist (VKA) warfarin in patients with APS who were “triple positive” for antiphospholipid antibodies (APLAs) and had had a thrombotic event (venous, arterial, or microthrombosis)., In multivariate analysis, the triple-positive profile was associated with a higher risk of relapse (HR 1.63; 95% CI 1.04 to 2.55; p=0.031). Conclusion: The triple-positivity is associated with a higher risk of relapse and obstetrical complications. Keywords: antibodies, anticardiolipin; antiphospholipid syndrome; autoimmune diseases..
Antiphospholipid syndrome occurs when the immune system mistakenly produces antibodies that make blood much more likely to clot. Antibodies usually protect the body against invaders, such as viruses and bacteria., The isolated presence of aCL antibodies is associated with the lowest risk of thrombosis, while triple positive aPLA, defined as the concomitant positivity of LA, aCL and aβ2GPI antibodies independently of their isotype, is associated with the highest risk [1]., CONCLUSIONS: Patients with triple-antibody positive antiphospholipid antibody syndrome are among the highest risk for developing CTEPH. Management of acute on chronic thrombus and CTEPH requires a multidisciplinary approach., The antiphospholipid syndrome is a systemic autoimmune disease defined by thrombotic or obstetrical events that occur in patients with persistent antiphospholipid antibodies. 1 Thrombotic, Triple-positive antiphospholipid syndrome (APS) had significantly more frequently obstetrical features, non-criteria manifestations and positive antinuclear autoantibodies, with a younger age at diagnosis., Although diverse clinical findings are noted in the different APA groups, the data implies that the degree of APA positivity—especially triple positivity—is strongly associated with an increased risk of thrombotic events (12 of the 19 patients who were triple positive had thrombotic event)..