сроки гарантийного ремонта при отсутствии запчастей
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сроки гарантийного ремонта при отсутствии запчастей, G2-M DNA damage checkpoint - Wikipedia, Cell Cycle: G2/M DNA Damage Checkpoint Regulation, G2M/DNA Damage Checkpoint | Cell Signaling Technology, HALLMARK_G2M_CHECKPOINT - GSEA-MSigDB, G2/M DNA 损伤检查点 | Cell Signaling Technology, G2 Phase Cell Cycle Checkpoint - an overview - ScienceDirect, Analyzing the G2/M checkpoint - PubMed.
Check supported browsers Your technical details and browser version: Request ID: 954540e799cdc82c-IAD IP: 64.71.32.72 UTC time: 2025-06-23T16:10:05+00:00 Browser: Mozilla/5.0 (Windows NT 6.1) AppleWebKit/536.11 (KHTML, like Gecko) Chrome/20.0.1132.47 Safari/536.11 About ScienceDirectRemote accessShopping cartAdvertiseContact and supportTerms and conditionsPrivacy policyCookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply. , The G2-M DNA damage checkpoint is an important cell cycle checkpoint in eukaryotic organisms that ensures that cells don't initiate mitosis until damaged or incompletely replicated DNA is sufficiently repaired., G2/M checkpoint is the second checkpoint within the cell cycle. This checkpoint prevents cells with damaged DNA from entering the M phase, while also pausing so that DNA repair can occur..
The G2/M DNA damage checkpoint serves to prevent the cell from entering mitosis (M-phase) with genomic DNA damage. Specifically, the activity of the Cyclin B-cdc2 (CDK1) complex is pivotal in regulating the G2-phase transition wherein cdc2 is maintained in an inactive state by the tyrosine kinases Wee1 and Myt1., Human Gene Set: HALLMARK_G2M_CHECKPOINT For the Mouse gene set with the same name, see HALLMARK_G2M_CHECKPOINT, G2/M DNA 损伤检查点可防止带有基因组 DNA 损伤的细胞进入有丝分裂（M 期）。 特别指出的是，Cyclin B-cdc2 (CDK1) 复合体对调节 G2 转变非常重要，此时 cdc2 由酪氨酸激酶 Wee1 和 Myt1 维持在灭活状态。 人们认为，当细胞进入 M 期时，激酶 Aurora A 和辅因子 Bora 协同作用，激活 PLK1，后者反过来可激活磷酸酶 cdc25 以及下游 cdc2 的活性，因此建立一个扩增反馈环，有效驱动细胞进入有丝分裂。 重要的是，DNA 损伤诱因会激活 DNA-PK/ATM/ATR 激酶，后者经过两个并行级联最终用于失活 Cyclin B-cdc2 复合体。, The G2 checkpoint (also known as the G2/M checkpoint) prevents cells from initiating mitosis when they experience DNA damage during G2, or if they progress into G2 with some unrepaired damage inflicted in previous S phase or even G1 phase., The G2 checkpoint prevents cells from entering mitosis when DNA is damaged, providing an opportunity for repair and stopping the proliferation of damaged cells. Because the G2 checkpoint helps to maintain genomic stability, it is an important focus in understanding the molecular causes of cancer., The G 2 /M checkpoint is regulated by proteins that modify or sequester the components of the Cyclin B /Cdc2 kinase complex, the principal enzymatic activity responsible for the initiation of mitosis..