средняя стоимость 1 квадратного метра в подмосковье
Главное меню:
Интересное
средняя стоимость 1 квадратного метра в подмосковье, How Does Cystic Fibrosis (CF) Cause Nasal Polyps?, Why Do Cystic Fibrosis Patients Get Nasal Polyps?, Etiology of Nasal Polyps in Cystic Fibrosis: Not a Unimodal Disease, Nasal Polyps in Cystic Fibrosis Patients: Causes, Symptoms, and , Nasal Polyps in Cystic Fibrosis - CHEST, Nasal Polyps - StatPearls - NCBI Bookshelf, Nasal Polyps and Cystic Fibrosis: The Hidden Dangers No One Talks About.
The most striking feature in these NPs was the presence of neutrophils in 4 of 10 samples — something that we almost never observe in idiopathic NPs of non-CF patients. The presence of neutrophils likely reflects trafficking of the cells in response to chemotactic stimuli different from those found in the NPs of non-CF patients. The distinguishing feature of CF lower airway disease is the almost universal colonization with bacteria — typically, gram-negative organisms. Although this is not the focus of the present study, it is reasonable to argue that CF similarly predisposes patients to colonization of the sinuses with bacteria and biofilm formation. Neutrophilia would then reflect the migration of these cells from the vasculature in response to this process. A role for PMNs is further supported by our studies regarding granulocyte biomarker expression in sinus secretions. As sinus secretions were obtained during routine clinic visits and not as a part of the polypectomy, we cannot directly correlate expression of mediators in mucus samples with polyp histology. Despite this caveat, as with the NPs, markedly elevated concentrations of myeloperoxidase were seen in half of these specimens, and again, this is something not routinely observed in non-CF chronic sinus disease. Van Zele et al found elevated levels of myeloperoxidase (as well as CXCL8 [IL-8]) in CF-derived sinus secretions, also pointing to a prominent role for PMNs. Even more impressive were our extracellular DNA concentrations, which were elevated in all of the CF specimens and to an extent higher than those we have observed in non-CF disease. Extracellular DNA is primarily derived from granulocytes, secreted as a component of neutrophils and eosinophils (mitochondrial-derived and nuclear-derived DNA nets, respectively) as part of their antibacterial response., In addition, extracellular DNA reflects cellular necrosis and the presence of inhibitors of phagocytosis of apoptotic bodies. These striking elevations in DNA content contribute to the viscosity of secretions and the inability to clear them (even with surgery and postsurgical irrigations) and will thereby contribute to the infection-remodeling-infection process. Elevations in DNA content are also consistent with reports that in attempts to reduce viscosity in the lung, CF secretions respond best to DNase.- This approach is being tested as a therapeutic option following sinus surgery. Administration of dornase alpha between 4 weeks and 12 months after surgery was associated with improved nasal symptoms and rhinoscopic findings. A recent double-blind placebo-controlled study found that dornase alpha improved quality-of-life outcome measures in subjects who had previously undergone sinus surgery., Other symptoms include a runny nose, facial pain, loss of sense of smell, and, rarely, nose bleeds. The thick mucus created by cystic fibrosis leads to chronic (constant, long-term) sinus congestion and frequent sinus infections, which doctors believe cause nasal polyps to develop., Nasal polyps are common in patients with cystic fibrosis (CF), affecting between 6% and 48% of this population. This study aimed to investigate the implications (symptoms, endoscopic findings, laboratory correlations) of nasal polyps in CF patients and their impact on overall health..
The objective was to determine whether the polyp subtypes observed in cystic fibrosis (CF)–related sinusitis were similar to those observed in non–CF-related sinusitis. Polyp and mucus samples were collected from CF patients who presented for sinus , Understanding the relationship between CF and nasal polyps is essential for early detection and effective management. This article delves into the causes, symptoms, diagnosis, and treatment options for nasal polyps in cystic fibrosis patients, offering valuable insights for patients, caregivers, and healthcare providers., Nasal polyps frequently appear in patients with cystic fibrosis (CF). The aims of this study were to focus on what problems (symptoms, endoscopic findings, and laboratory correlates) nasal polyps cause the CF patient, and how these correlate to the total health situation of this patient group., Nasal polyps are benign, inflammatory outgrowths of the sinonasal mucosa that can lead to chronic nasal obstruction, congestion, and diminished quality of life. These lesions are commonly associated with chronic rhinosinusitis but may also occur in the context of systemic diseases such as cystic fibrosis and aspirin-exacerbated respiratory disease., Nasal polyps are a common yet often overlooked complication in cystic fibrosis (CF) patients. While many are aware of the primary symptoms of CF, such as difficulty breathing and digestive issues, the hidden dangers of nasal polyps can be life-altering. In this article, we will unveil the lesser-known risks associated with nasal polyps in CF patients that could drastically affect their quality , Nasal polyps are common in cystic fibrosis (CF). Nasal polyps in children should prompt appropriate investigations for the potential diagnosis of CF. Possible etiologies for nasal polyp formation in CF include direct consequence of ΔF508 affecting chromosome 7, colonization with microorganisms including Pseudomonas aeroginosa and fungi, and IgE-mediated inflammation. Neutrophils are more .