Primary safety and tolerability endpoints were assessed in all vaccine recipients by reactogenicity for the first 7 days, adverse events for the first 28 days, and serious adverse events throughout the study., Safety and tolerability of the cAd3-Marburg vaccine were defined by the occurrence of solicited local and systemic reactogenicity signs and symptoms for 7 days after vaccination, change from baseline for safety laboratory measures, occurrence of adverse events for 28 days after vaccination, and the occurrence of serious adverse events and new , Background To determine the immunogenicity, efficacy, reactogenicity, and safety of a single dose of recombinant adenovirus type-5 vectored COVID-19 vaccine (Ad5-nCoV, 5 × 10 10 viral particles per 0.5 mL dose), we conducted a single-dose, randomised, double-blind, placebo-controlled, parallel group (3:1 Ad5-nCoV:placebo), phase 3 trial (Prometheus)., The main objective of this study was to estimate the reactogenicity within 7 days after each COVID-19 vaccine dose, and the primary outcome was the proportion of individuals who reported local or systemic adverse effects within 7 days of the first and second vaccine doses., ABSTRACT Background: The literature review on the immunogenicity and safety of adenovirus-based vector vaccines for COVID-19 presents a detailed examination of various studies that contribute to understanding the effectiveness and safety profiles of these vaccines. Literature Review: The systematic review conducted by (A. R. Mohamed Hussein et al., 2022) emphasizes that the benefits of , Stuart A, Shaw RH, Liu X, et al. Immunogenicity, safety, and reactogenicity of heterologous COVID-19 primary vaccination incorporating mRNA, viral-vector, and protein-adjuvant vaccines.