сосудосуживающие капли в нос для детей от гайморита
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сосудосуживающие капли в нос для детей от гайморита, Major roles of the circadian clock in cancer - PMC, The diverse roles of the circadian clock in cancer - Nature, The role of circadian clocks in cancer: Mechanisms and , Clockwork in cancer: the importance of the circadian rhythm , MYC and the clock in non-small cell lung cancer - Projects , Clocking cancer: the circadian clock as a target in cancer , Prediction of lung adenocarcinoma prognosis and diagnosis .
Check supported browsers Your technical details and browser version: Request ID: 970a26171de0cc72-IAD IP: 64.71.32.82 UTC time: 2025-08-17T15:19:16+00:00 Browser: Mozilla/5.0 (Windows NT 6.1) AppleWebKit/536.11 (KHTML, like Gecko) Chrome/20.0.1132.47 Safari/536.11 About ScienceDirectRemote accessShopping cartAdvertiseContact and supportTerms and conditionsPrivacy policyCookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply. , However, according to the International Agency for Research on Cancer (IARC) and other recent research, when the human circadian clock is disrupted, the likelihood of developing cancer, including lung cancer, intestinal cancer, and breast cancer, dramatically increases 5, 40 – 46., We discuss the divergent evidence indicating tissue-specific roles of the circadian clock in different cancer types and the potential link between circadian misalignment and early-onset.
In the present review, we describe the composition of circadian rhythm system. We highlight the function and mechanism of clock genes in cancer pathogenesis and progression. Moreover, their potential clinical implications as prognostic biomarkers and therapeutic targets have been addressed., The production of lung metastasis due to melanoma cells follows a circadian pattern. Neutrophils that collect in the lungs following a time-dependent way regulate the duration of this process., We will use cell and animal models of MYC-driven lung tumorigenesis to understand the role of MYC in the molecular clock and metabolic oscillations in this disease, and in particular, if MYC disruption of the clock is a feature of tumor progression., Disruption of the cellular pathway modulating endogenous 24-hour rhythms, referred to as ‘the circadian clock’, has been recently proven to be associated with cancer risk, development and progression., This study has successfully constructed a risk model for lung adenocarcinoma prognosis, utilizing circadian rhythm as its foundation., Experimental data in animals and cell cultures further supports the role of the cellular circadian clock in coordinating cell division and DNA repair, and disrupted cellular clocks accelerate cancer cell growth..