For chronic fatigue syndrome, some basic questions to ask your health care team include: What are the possible causes of my symptoms or condition? What tests do you recommend? If these tests don't pinpoint the cause of my symptoms, what additional tests might I need?, Nobody knows what causes chronic fatigue, but some experts hypothesize that it might start after you get the flu, a cold or the Epstein-Barr virus (which causes mononucleosis), triggering changes in your central nervous system. Even the COVID-19 infection may trigger chronic fatigue in some patients., Chronic fatigue syndrome. Migraine and other types of headaches. Interstitial cystitis, also called painful bladder syndrome. TMJ disorders. Anxiety. With fibromyalgia, many researchers think nerves are affected in a way that causes the brain and spinal cord to change. This change involves an irregular rise in levels of certain chemicals in , Ongoing fatigue affects quality of life and state of mind. Most of the time fatigue can be traced to one or more lifestyle issues, such as poor sleep habits or lack of exercise. Fatigue can be caused by a medicine or linked to depression. Sometimes fatigue is a symptom of an illness that needs treatment. Call 911 or your local emergency number, Chronic kidney disease, also called chronic kidney failure, involves a gradual loss of kidney function. Your kidneys filter wastes and excess fluids from your blood, which are then removed in your urine. Advanced chronic kidney disease can cause dangerous levels of fluid, electrolytes and wastes to build up in your body., Chronic inflammation: A look at its causes and symptoms. It’s not easy to pinpoint the cause of chronic inflammation. Some experts think that it occurs when the immune system goes awry. Persistent fatigue. Difficulty sleeping. Joint or muscle pains. Mental health conditions, such as depression or anxiety. Constipation, diarrhea or acid .