According to The International Staging System for Lung Cancer [], survival time for patients with MPE is worse in all stages of lung cancer []. Currently, the anatomical extent of MPE, as determined by the TNM staging system, is the most important prognostic tool for lung cancer. In 2007, The International Association for Study of Lung Cancer established that the presence of pleural effusion results in the designation of T4 disease. The presence of MPE is considered as metastatic disease (M1b) []. The survival time following diagnosis ranged from 1 to 96 months (median: 5 months) in the patients in our study (Table ). Sears and Hajdu [] demonstrated identical results to our study, with an average survival of 5 months or less following the diagnosis of MPE. In our study, patients with ovarian cancer and MPE had a longer survival (21 months, range: 5.0–46 months) than those with cancers of other primary sites (Table ). The most frequent extra-abdominal metastatic site in cases of ovarian carcinoma is the pleural cavity [,]. The median survival in a group of 214 patients with ovarian carcinoma and MPE (stage IV) was 24 months [,]. In a study by Anevlavis et al. [], patients with lymphoma had the best median survival (26 months), and those with ovarian and breast carcinomas had the second best survival times (18 and 15 months, respectively). In 120 cases of MPE reported by Martinez-Morangon et al. [], the overall survival was 9 months., Malignant pleural effusion causing dyspnea is not uncommon in certain advanced malignancies and may contribute to significant suffering at the end of life. A study of 298 patients with malignant pleural effusion noted that the presence of leukocytosis, hypoalbuminemia, and hypoxemia was associated with a poorer prognosis., Keywords: Neoplasm, Malignant pleural effusion, Prognosis, Analysis, Survival. Background. A malignant pleural effusion (MPE) is often the first sign of cancer and it is a prognostic factor in patients with advanced disease..