TALZENNA is a prescription medicine used alone to treat adults with a certain type of breast cancer (gBRCA-mutated, HER2-) that has spread to other parts of the body (locally advanced or metastatic). Your healthcare provider will perform a test to make sure that TALZENNA is right for you. It is not known if TALZENNA is safe and efective in children., PARP inhibitors and metastatic breast cancer treatment Olaparib and talazoparib are used to treat HER2-negative metastatic breast cancer in people who have a BRCA1 and BRCA2 (BRCA1/2) inherited gene mutation and have been treated with chemotherapy at least once in the past (including chemotherapy for early breast cancer)., Women with stage IV breast cancer are most often treated with hormone therapy, chemotherapy, targeted therapy, immunotherapy, or some combination of these. Surgery or radiation might be used to help prevent or treat symptoms., On October 16, the Food and Drug Administration (FDA) approved the PARP inhibitor Talzenna (talazoparib) for people with locally advanced or metastatic HER2 negative breast cancer who carry hereditary BRCA gene mutations. A recent clinical trial showed that Talzenna reduced disease progression by 46 percent compared with chemotherapy., What is targeted therapy for breast cancer? Targeted therapy for breast cancer refers to treatments or drugs that specifically target cancer cells while leaving normal cells mostly unscathed. To develop a new targeted therapy for breast cancer, researchers must first uncover the factors that drive normal cells to become breast cancer cells., TALZENNA was initially approved in the U.S., EU, and multiple other regions as a single agent for the treatment of adult patients with deleterious or suspected deleterious gBRCAm HER2-negative locally advanced or metastatic breast cancer..