Humate-P (Antihemophilic factor/von Willebrand factor complex [human]) Overview Humate-P is approved by the Food and Drug Administration (FDA) to control and prevent bleeding in adults with hemophilia A. Humate-P is also used to treat bleeding episodes and for perioperative (before,… read more, Read more about Wilate Xyntha Xyntha ® (antihemophilic factor [recombinant]) is a recombinant factor VIII indicated for the on-demand treatment, perioperative management, and routine prophylaxis of bleeding in patients with hemophilia A. It temporarily replaces FVIII in patients with hemophilia A to aid in hemostasis., Hemophilia A (HA) and hemophilia B (HB) are the most common severe bleeding disorders. Replacement therapy, providing the missing coagulation factor, has been the mainstay of treatment both prophylactically and to treat bleeding. Despite widespread availability of safe and effective replacement therapy, patients with HA and HB continue to experience a tremendous burden of treatment , , , .