Zepbound (tirzepatide) can cause side effects that range from mild to serious. More common side effects include nausea, diarrhea, and constipation. If side effects from Zepbound become, Here are ten common side effects of Tirzepatide and strategies to combat them. 1. Nausea and vomiting. Nausea is the most reported side effect of Tirzepatide. In clinical trials, up to 29% of people taking Zepbound for weight loss experienced nausea, and 18% reported it with Mounjaro for diabetes. Vomiting is less common but still noteworthy., Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines., The most common side effects of tirzepatide include gastrointestinal problems like nausea, vomiting, diarrhea, and constipation. Less common – but more serious – risks include pancreatitis, kidney injury, gallbladder disease, hypoglycemia, and diabetic retinopathy., Some common side effects include nausea, diarrhea or constipation, stomach pain, and pain or redness near the injection site. Zepbound is given as a weekly injection, Seek medical care or call 911 at once if you have the following serious side effects: Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, coordination loss, unsteady, very stiff muscles, high fever, profuse sweating, or tremors;.