смотреть онлайн фильм псы войны с хорошим переводом
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смотреть онлайн фильм псы войны с хорошим переводом, The sprint to an osteoarthritis cure has begun - UCLA Health, Osteoarthritis Breakthrough: New Research Shows That the Condition May , Research breakthrough shows hope for millions afflicted by , Joints that could heal themselves? Researchers could get there in 5 , From Pain to Progress: New Treatments for Knee Osteoarthritis, 2024's Breakthroughs in Joint Replacement and Osteoarthritis Treatment , Osteoarthritis Year In Review 2024: Rehabilitation and outcomes.
Osteoarthritis, the third-most common cause of disability in the United States, is currently incurable. This degenerative disease causes joint tissues to break down over time, often leading to debilitating chronic pain.“With rheumatoid arthritis, an autoimmune disease in which the abnormal biology is more easily defined, there have been all sorts of advances in the last 20 years. With osteoarthritis, we haven't made any progress,” says , an orthopedic surgeon and clinician-scientist faculty member at UCLA’s David Geffen School of Medicine. He says he is all too familiar with how osteoarthritis can impair his patients’ quality of life.For the 32.5 million Americans suffering from osteoarthritis, surgery offers an imperfect treatment, and the overall economic burden of the disease in the United States is estimated at more than $100 billion annually.With that burden in mind, researchers at UCLA Health are collaborating with teams at Duke Health and Boston’s Children’s Hospital to develop an affordable, injectable therapy to regenerate damaged joints.The multi-institutional team is one of five funded by , an agency within the U.S. Department of Health and Human Services (HHS). The goal of the ARPA-H Novel Innovations for Tissue Regeneration in Osteoarthritis (NITRO) program is to “create and commercialize injectable and implantable regenerative therapies for osteoarthritis.”Working alongside Dr. Kremen, the UCLA Department of Orthopaedic Surgery research team also includes professor and vice-chair for research, and Weiguang Wang, PhD, an assistant research faculty member. In a collaborative effort translating bench science into a bedside treatment, all three of these investigators have developed innovative technologies that, when combined, lead to a novel multimodal treatment approach.“With a disease as complex as osteoarthritis, it is unlikely that there is going to be a cure with a single drug,” Dr. Lyons says. “What is unique about our team is that we have a group of collaborators with many different ideas, and we’re putting them together to create a more holistic solution to this problem.”Taking a cue from the embryo, who is a developmental biologist, researchers have been studying the signaling pathways that cause cartilage to develop in utero during early development.Once Drs. Lyons, Wang and Kremen connected, the scientists wondered if they could target the same pathways to regenerate damaged cartilage and bone tissue in adult patients suffering from osteoarthritis.“Many of the same pathways that were used during early development are redeployed when tissues try to repair themselves,” Dr. Lyons says.While developmental biology studies offer important clues about which pathways might be best targeted to treat osteoarthritis, there are significant differences between newly formed joints and adult joints. Those include barriers like inflammatory pathways and a diminished pool of cells capable of regeneration and repair in adults.To test how well these pathways might be employed to repair joint degeneration, the UCLA research team has used both genetic and pharmacologic approaches in mouse models, to identify several drugs that have the potential to repair articular cartilage and its underlying bone.The will allow the UCLA Health team and their collaborators — who have also identified potential drugs that can slow osteoarthritis progression — to identify combinations of these specialized drugs and optimized drug delivery approaches.In addition to using animal models, the researchers will also be testing their strategies on a so-called “joint-on-a-chip” platform, which mimics the healthy or diseased features of joints inside of the body.Ultimately, the research team plans to develop three separate types of injectables that patients would receive once per year: One that targets joint tissues; another that targets adjacent bone; and a systemically administered drug that could treat cartilage tissues in patients who have osteoarthritis in multiple joints.At the end of five years, Dr. Kremen says, the researchers plan to have completed the testing of these treatments in phase I clinical trials which will be conducted at UCLA.“ARPA-H is really focused on commercialization and affordability,” Dr. Kremen says. “They have an ambitious timeline, because they, and we, want to get these therapies into people as soon as possible.”, He says he is all too familiar with how osteoarthritis can impair his patients’ quality of life. For the 32.5 million Americans suffering from osteoarthritis, surgery offers an imperfect treatment, and the overall economic burden of the disease in the United States is estimated at more than $100 billion annually., A groundbreaking study from the University of Adelaide reveals that osteoarthritis may be reversible through a new treatment targeting Gremlin 1 gene-marked stem cells. With promising results from stimulating these cells in mice, and human trials in progress following a successful five-year study, this research challenges the traditional view of osteoarthritis and suggests a potential paradigm .
A discovery led by researchers from the University of Leeds and Leeds Teaching Hospitals NHS Trust (LTHT), and funded by charity Versus Arthritis, could offer hope for millions of people across the UK suffering with chronic pain and stiffness caused by osteoarthritis of the knee., The Novel Innovations for Tissue Regeneration in Osteoarthritis (NITRO) program was the first created under ARPA-H, a new federal agency to support “high-impact solutions to society's most challenging health problems.”, In recent years, new treatments for knee osteoarthritis have emerged, offering less invasive options and more straightforward paths to recovery., The year 2024 stands as a landmark in orthopedic medicine, with breakthroughs in joint replacement and osteoarthritis treatment offering new hope and improved quality of life for patients globally., This Year in Review presents key highlights from recent research relating to osteoarthritis rehabilitation and its outcomes, defined as any non-pharmacological and non-surgical treatment that aims to improve osteoarthritis symptoms at any joint. Three databases (Medline, Embase, and CINAHL Plus) were searched between 1 March 2023 to 12 March 2024. Relevant studies were chosen based on the , Received 2024 Jan 17; Accepted 2024 Jan 19; Collection date 2024. Keywords: osteoarthritis, knee, treatment, extracellular vesicles, articular cartilage, regenerative .