KISQALI is a kinase inhibitor indicated in combination with an aromatase inhibitor as initial endocrine-based therapy for the treatment of postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer. (1), Learn about KISQALI, a CDK4/6 inhibitor used to treat patients with HR+/HER2- metastatic breast cancer (mBC). See full Prescribing & Safety Information., For advanced-stage or metastatic breast cancer, Kisqali is prescribed in combination with an aromatase inhibitor (which reduces the body’s ability to produce estrogen) or Faslodex (which blocks the effects of estrogen on hormone receptor-positive breast cancer cells) as a first hormonal therapy treatment., What is KISQALI? KISQALI is a prescription medicine used to treat adults with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer that has gotten worse or has spread to other parts of the body (advanced or metastatic), in combination with:, In younger women with advanced breast cancer, ribociclib (Kisqali) plus hormone therapy shrank metastatic tumors better than standard chemotherapy treatments., KISQALI is a prescription medicine used to treat adults with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer that has gotten worse or has spread to other parts of the body (metastatic), in combination with:.