Ulcerative colitis is a form of IBD that causes inflammation in your colon. People experience symptom flare-ups and also periods without symptoms. Treatment options include medications and surgery. Medications. Healthcare providers use several medications (alone or in combination) to calm inflammation in your large intestine. Reducing the , Ulcerative Colitis Treatment. The goal in treating ulcerative colitis is to reduce the inflammation, hopefully leading to remission. The two leading treatment options are medication and surgery. Approximately 70 percent of patients respond well to medication and go into remission. For those who did not respond well to medication, surgery is an , People with ulcerative colitis typically need lifelong treatment with medicines unless they have surgery to remove the colon and rectum. Which medicines your doctor prescribes will depend on how severe ulcerative colitis is. Ulcerative colitis medicines that reduce inflammation in the large intestine include, Aminosalicylates, also known as 5-ASAs, are usually the first treatment option for mild to moderate ulcerative colitis. These medications help reduce inflammation and allow damaged tissue in the , Ulcerative colitis treatment falls into three categories: medication, diet, and surgery. These approaches effectively manage symptoms and improve quality of life., Ulcerative colitis is a chronic inflammatory condition that attacks your colon or large intestine. Treatments for ulcerative colitis can include pills, enemas, injections, or surgery. The goal of treatment is to manage your ulcerative colitis symptoms, so they don’t interfere with your quality of life..