Xywav is also approved to treat excessive daytime sleepiness and cataplexy (sudden muscle weakness) related to narcolepsy. Side effects of Xywav when used to treat these narcolepsy-related , In August 2021, the FDA approved Xywav as a treatment option for IH. In fact, it’s the only medication that’s FDA-approved for this condition. Xywav was originally FDA-approved in 2002 to treat excessive daytime sleepiness (EDS) and cataplexy Journal of Clinical Sleep Medicine. Schneider, L. D., et al. (2023)., Excessive Daytime Sleepiness (EDS) with Narcolepsy. 1-3 . Authorization of 12 months may be granted for continued treatment of excessive daytime sleepiness (EDS) with narcolepsy when the member has demonstrated beneficial response to treatment as defined by a decrease in daytime sleepiness with narcolepsy from baseline. Idiopathic hypersomnia. 1,5, Xywav significantly reduced the excessive daytime sleepiness that is a typical hallmark of the sleep disorder idiopathic hypersomnia. ESS score of 16.1 (3.6), indicating substantial excessive daytime sleepiness. During the Xywav open the best cutoff to differentiate individuals with untreated idiopathic hypersomnia from a control , XYWAV ® (calcium, magnesium, potassium, and sodium oxybates) oral solution, 0.5 g/mL total salts (equivalent to 0.413 g/mL of oxybate) is indicated for the treatment of cataplexy or excessive daytime sleepiness (EDS) in patients 7 years of age and older with narcolepsy, and for the treatment of idiopathic hypersomnia (IH) in adults., Xywav is the only low-sodium oxybate approved by the U.S. Food and Drug Administration for the treatment of cataplexy or excessive daytime sleepiness (EDS) in patients 7 years of age and older with narcolepsy and for adults with idiopathic hypersomnia..